Pemanfaatan α-Tokoferol untuk Meningkatkan Profil Superoksida Dismutase (SOD) Ginjal Tikus di Bawah Kondisi Stres

Authors

  • Tutik Wresdiyati
  • Made Astawan
  • Diini Fithriani
  • I Ketut Mudite Adnyane
  • Mustika Hidayati

DOI:

https://doi.org/10.24002/biota.v13i3.2568

Keywords:

α-tocopherol, kidney, stress, superoxide dismutase, immunohistochemistry

Abstract

Stress condition has been reported decreased the level of intracellular antioxidant, especially superoxide dismutase (SOD). The condition can lead to certain cell impairment and finally can reach to the degenerative processes, such as aging and carcinogenesis. We need several alternative treatments to solve the severe problem under antioxidant defiency status caused by stress condition. The aim of the study was to observe the effect of α-tocopherol on increasing the profile of superoxide dismutase (SOD) in the kidney of rats under stress condition. The stress condition was achieved by five days fasting together with smimming for 5 min/day and only drinking distiled water ad libitum. α-tocopherol was orally administrated at a dose of 60 mg/Kg/BW/day for seven days. By measuring SOD activity and Cu,Zn-SOD imunohistochemically, showed that α-tocopherol has effect on increasing the profile of intracellular antioxidant in the rats kidney tissue under stress condition.

Downloads

Published

15-10-2019

How to Cite

Wresdiyati, T., Astawan, M., Fithriani, D., Adnyane, I. K. M., & Hidayati, M. (2019). Pemanfaatan α-Tokoferol untuk Meningkatkan Profil Superoksida Dismutase (SOD) Ginjal Tikus di Bawah Kondisi Stres. Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati, 13(3), 147–155. https://doi.org/10.24002/biota.v13i3.2568

Issue

Vol 13, No 3 (2008): October 2008

Section

Articles

License

Authors who publish with Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati agree to the following terms:

  • Authors retain copyright and grant the Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati right of first publication. Licensed under a Creative Commons Attribution-NonCommercial 4.0 International License that allows others to share the work with an acknowledgment of the work's authorship and initial publication in this journal.
  • Authors are able to enter into separate, additional contractual arrangements for the non-exclusive distribution of the journal's published version of the work (e.g., post it to an institutional repository or publish it in a book), with an acknowledgment of its initial publication in Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati, and as long as Author is not used for commercial purposes.