Uji Efek Inhibitorik Komponen Bioaktif Bawang Putih (Allium sativum) terhadap Lanosterol 14α-demethylase pada Candida albicans melalui Studi In Silico

Authors

  • Aditya Tri Ananda
  • Alsya Firdausi Nuzula
  • Devi Ayu Safitri

DOI:

https://doi.org/10.24002/biota.v5i2.2940

Keywords:

Gallic Acid, Candidiasis, Candida albicans, lanosterol 14α-demethylase

Abstract

Candida albicans is a unicellular fungi which causes candidiasis in human and livestock animals especially chicken. Candidiasis could reduce productivity significantly by early culling and causing a great deficit in the farm. Allium sativum or garlic is widely known as herbal which has an inhibitory effect in fungi’s growth. This research’s aim is to prove the effectivity of bioactive compound in Allium sativum to lanosterol 14α-demethylase which plays a role in ergosterol synthesis as a basic structure in fungi’s cell membrane. The ligand sheet retrieved from PubChem database and for the receptor in Protein Data Bank database. Molecular docking conducted by using Autodock Vina and then ligand-receptor complex is visualized with PyMOL and Ligplot+. From compounds that we have been analyzed, Gallic Acid has the most negative binding energy than other compounds have and it has the same amino acid residue with control. In conclusion of that, Gallic Acid in Allium sativum has potential as anti-candidiasis drug.

References

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Published

18-06-2020

How to Cite

Ananda, A. T., Nuzula, A. F., & Safitri, D. A. (2020). Uji Efek Inhibitorik Komponen Bioaktif Bawang Putih (Allium sativum) terhadap Lanosterol 14α-demethylase pada Candida albicans melalui Studi In Silico. Biota : Jurnal Ilmiah Ilmu-Ilmu Hayati, 5(2), 124–129. https://doi.org/10.24002/biota.v5i2.2940

Issue

Vol 5, No 2 (2020): June 2020

Section

Articles

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Copyright (c) 2021 Aditya Tri Ananda, Alsya Firdausi Nuzula, Devi Ayu Safitri

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